Mechanism of Action:
Tesamorelin:
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A GHRH (growth hormone-releasing hormone) analog.
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Stimulates the pituitary gland to release endogenous growth hormone (GH).
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Leads to increased IGF-1 (insulin-like growth factor-1) production, which mediates many GH effects.
Ipamorelin:
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A ghrelin receptor agonist (GHSR agonist) and selective growth hormone secretagogue.
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Stimulates GH release from the pituitary without significantly affecting cortisol or prolactin levels.
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Often used to enhance GH pulses and recovery.
Together: The combination amplifies GH release via two pathways (GHRH and ghrelin receptor), potentially creating a synergistic effect for more robust growth hormone secretion.
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