PT 141 (10 mg)

PT-141 works by activating melanocortin receptors (MC1R and MC4R) in the hypothalamus, a brain region responsible for regulating sexual behavior and arousal. Unlike PDE5 inhibitors (such as Viagra), which improve blood flow to the genitals, PT-141 directly influences the central nervous system (CNS) to enhance sexual desire.

Step-by-Step Action:

1. Melanocortin Receptor Activation

• PT-141 binds to MC4R receptors in the brain, which are linked to sexual function and arousal.
• This receptor activation triggers neurotransmitter release, leading to increased sexual desire and motivation.

2. Dopamine Release

• PT-141 stimulates dopamine, the "pleasure and reward" neurotransmitter, which plays a crucial role in sexual excitement and mood enhancement.

3. Enhanced Neural Signaling for Sexual Response

• The increased dopamine activity leads to heightened arousal, improved sexual satisfaction, and stronger sexual response in both men and women.
• Unlike PDE5 inhibitors, which primarily work on vascular function, PT-141's effects are neurological, meaning it works even for individuals with normal blood flow but low libido.

4. Increased Blood Flow as a Secondary Effect

• While PT-141 does not directly act as a vasodilator, its activation of the CNS indirectly improves blood flow, making it beneficial for men with erectile dysfunction (ED) and women with reduced sensitivity or arousal issues.

5. Why Is PT-141 Unique?
 

• Works for Both Men & Women (unlike Viagra, which is mainly for men)
• Does Not Depend on Blood Flow, making it effective for non-vascular causes of sexual dysfunction
• Long-Lasting Effects (can last 24-48 hours)

1.Boosts Sexual Arousal & Libido – Effective for men with erectile dysfunction (ED) and women with low sexual desire (HSDD).
2. Enhances Pleasure & Sensation – Increases dopamine levels, leading to heightened sexual satisfaction.
3. Works Independently of Blood Flow – Ideal for individuals who don’t respond well to PDE5 inhibitors like Viagra or Cialis.
4. Improves Mood & Reduces Stress – Can help relieve performance anxiety and low libido caused by stress or depression.
5. Long-Lasting Effects – Can last 24-48 hours, making it ideal for extended intimacy.

• Nausea (most common, dose-dependent)
• Flushing (warmth, redness in face or body)
• Mild headache or dizziness
• Temporary increase in blood pressure

1. People with Uncontrolled High Blood Pressure (Hypertension)

• PT-141 can cause temporary increases in blood pressure, making it risky for individuals with uncontrolled or severe hypertension.

2. Individuals with Cardiovascular Disease

• Since it affects the nervous system and blood pressure, those with heart disease, a history of heart attack, or stroke should consult a doctor before use.

3. Pregnant or Breastfeeding Women

• There are no safety studies on PT-141 in pregnancy or breastfeeding, so it should be avoided in these cases.

4. People with Severe Kidney or Liver Disease

• PT-141 is metabolized by the liver and excreted by the kidneys, so those with significant organ dysfunction may experience complications.

5. Individuals with a History of Nausea or GI Disorders

• Since nausea is the most common side effect, those prone to motion sickness, gastric issues, or severe nausea should use caution.

6. People Taking Certain Medications

• If you're on blood pressure medications, dopamine agonists/antagonists, or medications affecting the central nervous system, PT-141 may cause interactions.