MOTS-C (10mg)

• MOTS-c (Mitochondrial ORF of the 12S rRNA type-c) is a mitochondria-derived peptide (MDP).
• It’s encoded in mitochondrial DNA and acts like a signaling hormone.
• Primary actions:
• Regulates cellular metabolism by activating AMPK (AMP-activated protein kinase) → increases energy utilization and fat burning.
• Enhances insulin sensitivity → improves glucose uptake in muscle.
• Promotes fatty acid oxidation and reduces fat accumulation.
• Helps maintain metabolic homeostasis, especially under stress conditions (e.g., poor diet, aging).

• Improved metabolic health
• Increased insulin sensitivity → possible support for prediabetes, type 2 diabetes
• Weight and fat reduction (especially visceral fat)
• Increased exercise capacity & endurance
• Supports healthy aging → some research suggests longevity effects
• May improve mitochondrial function and resistance to cellular stress
• Neuroprotective effects are being investigated

Generally regarded as safe and well-tolerated in studies, but possible:

• Mild fatigue or drowsiness

• Temporary nausea or GI upset

• Mild injection site redness/irritation

• Rare: headache, dizziness, or short-term appetite suppression

Avoid or use cautiously in:

• Pregnant or breastfeeding women (no safety data)

• Children/adolescents (safety not studied)

• Patients with active cancer → as with many peptides, long-term safety is not well established

• Severe uncontrolled medical conditions (cardiovascular disease, liver/kidney disease) unless supervised by a physician

• People with known allergy to peptide formulations

MOTS-c is a mitochondria-derived peptide that acts like a metabolic regulator, improving insulin sensitivity, fat burning, energy, and endurance. It is being researched for anti-aging, obesity, and diabetes support, with a relatively clean side-effect profile.